
李怀标:博士, 副教授, 硕士/博士生导师
电子邮件:lihuaibiao@hust.edu.cn
ORCID iD: 0000-0003-4086-3321
通讯地址:湖北省武汉市航空路13号
学术经历:
2010年11月—2015年9月,德国耶拿莱布尼茨衰老研究所/耶拿大学, 博士
2015年10月—2019年3月,德国耶拿莱布尼茨衰老研究所,博士后
2019年3月—至今,华中科技大学同济医学院生殖健康研究所,副教授
研究方向:
1. 纺锤体定位和定向的调控机制
2. 选择性多聚腺苷酸化调控配子发生及胚胎发育的机制
3. 利用三维类器官培养技术和动物模型探讨器官发育和相关疾病的发生
承担项目: 华中科技大学人才引进基金,湖北省自然科学基金面上项目。
代表性论文:(*共同第一作者)
1. Zhou J, et al. NUDT21 regulates 3'UTR dynamics in epididymal principal cells to preserve sperm integrity. Development 2026, dev.205483.
2. Li S, et al. Dynamic regulation of astral microtubule growth in the meiotic spindle of mouse oocyte. Reproduction 2026, 171: xaaf013.
3. Cai Y, et al. Identification of YBX2 and TSKS As STK33 Interacting Proteins in Testicular Germ Cells. Reproductive Science 2025, 32(3):769-782.
4. Cai Y, et al. YBX2 modulates mRNA stability via interaction with YTHDF2 in endometrial cancer cells. Experimental Cell Research 2023, 427: 113586.
5. Li N, et al. CFIm-mediated alternative polyadenylation safeguards the development of mammalian pre-implantation embryos. Stem Cell Reports 2023, 18: 81-96.
6. Li H*, et al. CD44 deletion suppresses atypia in the precancerous mouse testis. Molecular Carcinogenesis 2019, 58: 621-626.
7. Li H, et al. Spindle misorientation of cerebral and cerebellar progenitors is a mechanistic cause of megalencephaly. Stem Cell Reports 2017, 9: 1071-1080.
8. Li H, et al. Impaired Planar Germ Cell Division in the Testis, Caused by Dissociation of RHAMM from the Spindle, Results in Hypofertility and Seminoma. Cancer Research 2016, 76: 6382-6395.
9. Li H*, et al. RHAMM deficiency disrupts folliculogenesis resulting in female hypofertility. Biology Open 2015, 4: 562-571.