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《Biology of Reproduction》亮点报道袁水桥教授课题组成果
来源:     日期:2020-03-06     浏览数:     【 字体:

2月26日,生殖医学领域国际权威期刊《Biology of Reproduction》 在“RESEARCH HIGHLIGHTS”专栏,以“UHRF1: a jack of all trades, and a master epigenetic regulator during spermatogenesis”为题,亮点报道了华中科技大学同济医学院生殖健康研究所袁水桥教授课题组发表在Nature Communications的研究成果(Juan Dong#, Xiaoli Wang#, Congcong Cao#, Yujiao Wen, Akihiko Sakashita, Si Chen, Jin Zhang, Yue Zhang, Liquan Zhou, Mengcheng Luo, Mingxi Liu, Aihua Liao, Satoshi H. Namekawa, Shuiqiao Yuan*. UHRF1 suppresses retrotransposons and cooperates with PRMT5 and PIWI proteins in male germ cells. Nature Communications. 2019, 10(4705), doi: 10.1038/s41467-019-12455-4.)。

节选亮点报道内容如下:

The recent study by Dong and colleagues adds to our knowledge about the essential roles that UHRF1 plays in vivo. Already recognized as a jack of all trades, this study establishes UHRF1 as a master regulator of epigenetic pathways during male germ cell development. Importantly, the observed infertility phenotype is highly relevant to human male reproduction as genetic polymorphisms in the human UHRF1 gene have been associated with oligospermia.

全文亮点报道链接如下:

https://academic.oup.com/biolreprod/advance-article-abstract/doi/10.1093/biolre/ioaa026/5758287?redirectedFrom=fulltext

生殖生物学(Biology of Reproduction)杂志是美国生殖研究学会的官方期刊,创刊迄今已50多年,发表关于生殖生物学领域的原创性研究成果,以及关于当前重要或有争议主题的综述和评论,一直是生殖生物学领域被引用最高的期刊。

文/王晓丽

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