博士，副教授，硕士生导师

联系方式

lchy2019@hust.edu.cn

科研与学术经历

l2022/9至今，华中科技大学同济医学院生殖健康研究所，副教授

l2019/03-2022/9，华中科技大学同济医学院生殖健康研究所，讲师

l2016/03-2019/03，华中科技大学同济医学院计划生育研究所，博士后，合作导师：熊承良教授

l2009/09-2015/12，中国科学院水生生物研究所，获得遗传学博士学位

研究方向

（1）妊娠相关疾病的病理机制研究

（2）斑马鱼模型进行环境污染物的胚胎毒性评价和机制研究

主持项目

l国家重点研发计划项目，2018YFC1004300，基于内外暴露监测的环境和行为因素对胚胎发育与妊娠影响研究，2019/01-2022/12，100万元

l国家自然科学基金青年科学基金项目，81601282，甲醛与TMBIM家族相关基因交互作用影响早期胚胎发育的分子机制研究，2017/01-2019/12，17.5万元

l武汉市青年科技晨光计划，与神经管缺陷发生相关的miR-9增强子区SNP和甲基化位点分析，2017/8-2019/8, 10万元

l湖北省卫生计生委青年人才项目，WJ2017Q018，神经管缺陷胚胎脑组织中miR-9增强子遗传学和表观遗传学状态的研究，2017/01-2018/12，4万元

l中国博士后科学基金面上资助第60批，一等资助，2016M600597，miR-9增强子在先天性神经管缺陷中的调控机制研究，2016/10-2019/03，8万元

发表论文

l Chen Y, Xiao L, Xu J, Wang J, Yu Z, Zhao K, Zhang H, Cheng S, Sharma S, Liao A^#, Liu C^#. Recent insight into autophagy and immunity at the maternal-fetal interface. J Reprod Immunol. 2022 Nov 29;155:103781.

l Fan Z, Yang Y, Hu P, Huang Y, He L, Hu R, Zhao K, Zhang H^#, Liu C^#. Molecular mechanism of ethylparaben on zebrafish embryo cardiotoxicity based on transcriptome analyses. Sci Total Environ. 2022 Jun 22;842:156785.

l Zong Y, Chen Y, Wang Y, Wang J, Yu Z, Ou Z, Chen J, Zhang H^#, Liu C^#. Induction of cardiotoxicity in zebrafish embryos by 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene through the JAK-STAT and NOTCH signaling pathways. Chem Biol Interact. 2022 Dec 1;368:110226.

l Chen Y, Xiao L, Zhao K, Zhang H, Shang X^#, & Liu C^#.2, 5-dichloro-1, 4-benuinone-induced neurodevelopmental toxicity in zebrafish embryos. Ecotoxicol Environ Saf. 2022 Sep 15;243:114007.

l Hu Z, He L, Wei J, Su Y, Wang W, Fan Z, Xu J, Zhang Y, Wang Y, Peng M, Zhao K, Zhang H, Liu C^#. tmbim4 protects against triclocarban-induced embryonic toxicity in zebrafish by regulating autophagy and apoptosis. Environ Pollut. 2021,May,15;277:116873.

l Y. Su, L. He, Z. Hu, Y. Li, Y. Zhang, Z. Fan, K. Zhao, H. Zhang^#, C. Liu^#, Obesity Causes Abrupt Changes in the Testicular Microbiota and Sperm Motility of Zebrafish. Front Immunol. 2021 Jun 25;12:639239.

l He L, Chen Y, Hu Z, Zhang Y, Wang Y, Wei J, Fan Z, Xu J, Peng M, Zhao K, Zhang H^#, Liu C^#. Evaluation of 3,4,4,9-trichlorocarbanilide to zebrafish developmental toxicity based on transcriptomics analysis. Chemosphere. 2021 Mar 29;278:130349.

l Wang Y, Yu Z, Fan Z, Fang Y, He L, Peng M, Chen Y, Hu Z, Zhao K, Zhang H^#, Liu C^#. Cardiac developmental toxicity and transcriptome analyses of zebrafish (Danio rerio) embryos exposed to Mancozeb. Ecotoxicol Environ Saf. 2021 Dec 15;226:112798.

l Su Y, He L, Zhao K, Zhang H, Mao Z^#, Liu C^#. Chronic exposure to organic oxygen-demanding pollutants at an environmentally realistic concentration affects sperm motility in zebrafish. Environ Toxicol Pharmacol. 2021 Jan;81:103523.

l Liu C, Wei J, Xu K, Sun X, Zhang H^#, Xiong C^#.(2019) CSE1L participates in regulating cell mitosis in human seminoma. Cell Proliferation. 2019, Mar;52(2):e12549.

l Wei J, Zhou T, Hu Z, Li Y, Yuan H, Zhao K, Zhang H, Liu C^#.(2018). Effects of triclocarban on oxidative stress and innate immune response in zebrafish embryos. Chemosphere. 210:93-101

l Zhou T, Wei J, Su Y, Hu Z, Li Y, Yuan H, Zhao K, Liu C^#, Zhang H^#. Triclocarban(TCC) at environmentally relevant concentrations induces the endoplasmic reticulum stress in zebrafish. Environmental Toxicology. 2019 Mar;34(3):223-232.

l Liu, C., Song, G., Mao, L., Long, Y., Li, Q., & Cui, Z. (2015). Generation of an Enhancer-Trapping Vector for Insertional Mutagenesis in Zebrafish. PloS one,10(10), e0139612.